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Interviews and other interesting materials :: PECULIARITIES IN THE SPECIFIC DIAGNOSTICS AND INTERPRETATION IN HIV INFECTION

PECULIARITIES IN THE SPECIFIC DIAGNOSTICS AND INTERPRETATION IN HIV INFECTION

Prof. Radka ArgirovaПроф. д.м.н. Радка Аргирова, вирусолог, Аджъбадем Сити Клиник ДКЦ и Токуда Болница, София

Преди да  опишем особеностите в специфичната диагностика на HIV-инфекцията,  ще дефинираме някои основни понятия от областта HIV/СПИН. HIV-инфекцията се определя като периодът от момента на заразяване с HIV до смъртта при естествен ход на инфекцията. СПИН е последната фаза на HIV инфекцията, като съществуват ясно определени критерии – клинични и лабораторни -  за поставяне на диагнозата  СПИН. Симптомите на остра/ хронична HIV инфекция при възрастни и деца са описани в Приложение 1 към чл.10,т.1 на Наредба N 47 на МЗ, обнародвана в ДВ, бр.103/29.12.2009 г.  В Приложение 2 към чл.10,т.2 на същата Наредба са описани индикаторните заболявания за СПИН.
Прозоречен период е времето между заразяването с HIV и появата в кръвта на биохимично измерими маркери на инфекцията (най-често  антитела, но като маркери могат да бъдат използвани и вирусспецифични антигени, както и вирусна РНК). Сероконверсия е моментът, в който се откриват биохимично измеримите маркери (най-често антитела към HIV, които най-вероятно се формират по-рано, отколкото се откриват). Практически, прозоречният период е времето между заразяването и откриването на антивирусните антитела. HIV антителата се откриват най-рано 2 седмици след заразяването, в 60-65% от случаите се откриват след 4 седмици, в 80% - след 6 седмици, в 90% - след 8 седмици и в 95-98% - след 12 седмици. При съвременните тестове от 4-то поколение освен анти-р24 антителата, се открива и р24 антигена – около 4-5 дни преди появата на антителата. Най-ранно определимият лабораторен маркер е HIV РНК, която пък се открива около 6-7 дни преди р24 антигена. Следователно, няма никакъв смисъл да се търсят специфични маркери на HIV преди началото на втората седмица след заразяването.

 

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Interviews and other interesting materials :: PECULIARITIES IN THE SPECIFIC DIAGNOSTICS AND INTERPRETATION IN HIV INFECTION